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Co activation of ER and LXR results in competitive intracellular signaling and cross modulation, as demonstrated by loss of function in vitro experiments whereby 27 OHC activity on LXR knocked down cells enhanced the induction of ER target genes, whereas in ER knocked down cells resulted in significant up regulation of LXR target genes 48 anastrozole vs tamoxifen quality of life A number of natural compounds and small molecule inhibitors have been identified that modulate the activation or inhibition of the Wnt signaling pathway in several different cancers
Co activation of ER and LXR results in competitive intracellular signaling and cross modulation, as demonstrated by loss of function in vitro experiments whereby 27 OHC activity on LXR knocked down cells enhanced the induction of ER target genes, whereas in ER knocked down cells resulted in significant up regulation of LXR target genes 48 anastrozole vs tamoxifen quality of life A number of natural compounds and small molecule inhibitors have been identified that modulate the activation or inhibition of the Wnt signaling pathway in several different cancers